INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ANTICANCER AND CYTOTOXIC ACTIVITY OF NEW SEMICARBAZONES AND THIOSEMICARBAZONES
Autor/es:
MORERA L P, DIGENARO S, CIFUENTE D.
Lugar:
SAN lUIS, ARGENTINA
Reunión:
Congreso; XXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2009
Institución organizadora:
SOCIEDAD DE BIOLOGIA DE CUYO
Resumen:
A series of new semicarbazones and thiosemicarbazones were synthesized from different aryl ketones. All compounds were tested for their in vitro anticancer properties against two cell lines CT26 (murine melamome) and B26 (murine colon cancer). The cytotoxic effects were investigated by means of May-Grunwald-Giemsa tinction (MGG) and tetrazolium salt assay (MTT). Apoptosis was detected by acridine orange / ethidium bromide (AO/EB) and it was confirmed by RT PCR evaluating the expressions of bcl-2 and BAX genes. Semi- and thiosemicarbazones showed high activity compared to the corresponding ketones. Flouroketones derivatives were the most actives.
