INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
SEMICARBAZONAS Y TIOSEMICARBAZONAS CON ACTIVIDAD ANTITUMORAL OBTENIDAS A PARTIR DE CETONAS AROMÁTICAS
Autor/es:
LUIS P. MORERA, DIEGO A. CIFUENTE, SILVIA DIGENARO Y CARLOS E. TONN
Lugar:
MENDOZA, ARGENTINA
Reunión:
Simposio; XVII SIMPOSIO NACIONAL DE QUIMICA ORGANICA; 2009
Institución organizadora:
SAIQO (SOCIEDAD ARGENTINA DE INVESTIGACION EN QUIMICA ORGANICA
Resumen:
A series of new semicarbazones and thiosemicarbazones were synthesized from different aryl ketones. Their structures were confirmed by RMN spectral data. All compounds were tested for their in vitro anticancer properties against two cell lines CT26 (murine melamome) and B26 (murine colon cancer). The cytotoxic effects were investigated by means of tetrazolium salt assay (MTT). Apoptosis was detected by acridine orange / ethidium bromide (AO/EB). Semi- and thiosemicarbazones showed high activity compared to the corresponding ketones. Flouroketones derivatives were the most actives.
