INTEQUI   20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Antibacterial screening of a coumarins group
Autor/es:
MASCOTTI M. L.; GARRO. H. A.; C. R. PUNGITORE; C. E. TONN; KURINA, M. B.; GIANNINI F.
Lugar:
San Luis
Reunión:
Congreso; XXVII Reuni¨®n Cient¨ªfica Anual de la Sociedad de Biolog¨ªa de Cuyo ¨C 2009; 2009
Institución organizadora:
Soc.de Biolog¨ªa de Cuyo
Resumen:
Coumarines are plant ubiquitous compounds fully distributed in families such as in Umbelliferae/Apiaceae and Rutaceae. They have been isolated as glycosides and/or in their free forms. It has been reported for them antifungal, antibacterial and, the most well-known, anticoagulant activity, the last one involved in defense mechanisms against predators. The objetive of this work was to evaluate antibacterial activity of 5-hidroxycoumarin (1), 3-acylcoumarin (2), coumaranone (3), 4-hidroxycoumarin (4), coumarin (5), 3-hidroxycoumarin (6), 7-hidroxycoumarin (7), 6-hidroxycoumarin (8), against Lactobacillus acidophilus, Bifidobacterium bifidum and Bacillus subtilis, from a commercial liophilyzated of gram+ bacterium, by microdilution agar assay. The results obtained, expresed as MIC (minimal inhibitory concentration), are: coumaranone (3) >250¦Ìg/mL, 3-acylcoumarin (2) and 6-hidroxycoumarin (8) 250¦Ìg/mL, 5-hidroxycoumarin (1) 125¦Ìg/mL, coumarin (5) 62.5¦Ìg/mL, 4-hidroxycoumarin (4), 7-hidroxycoumarin (7) and 3-hidroxycoumarin (6) <1.95¦Ìg/mL. It is known that pure compounds with MIC values lower than 25¦Ìg/mL are very promising as antimicrobial agents. Therefore hidroxylated coumarines in 3, 4 and 7 positions, show interesting activities, similar to those of eritromicin and gentamicine, well-known antibiotics.