Polienos funcionalizados con potencial actividad como juvenoides frente a Tenebrio molitor L

L. ARCE L, CEÑAL JP, SOSA ME, TONN CE

San Luis

Otro; XXX Reunión Anual de la Sociedad de Biología de Cuyo,; 2012

Sociedad de Biología de Cuyo,

Functionalized polyenes with potential juvenoid activity on Tenebrio molitor L. Juvenoids are juvenile hormone analogues, environmentally safe insecticides, that posses significant biological activity towards different insect pest species. A new approach to insect pest control is the use of substances that affect moulting and metamorphosis by mimicking juvenile hormones (JH juvenile hormones agonist) They are also called third-generation insecticides. The present research is aimed toward discovering the juvenoids properties of functionalized polyenes, obtained by chemical synthesis, The structures of the synthetic products and the relative stereochemistry were determined by a combination of high resolution MS, UV, 1H NMR, 13C NMR spectroscopy. The biological activity of compounds were evaluated using T. molitor as an insect model. Fifth instars of T. molitor were randomly selected. Two acetone solutions of each compound (60, 120g/l) were prepared. Test solutions were topically applied to the ventral surface of the thoracic segments with a microsyringe (2l/larvae). Controls were treated with the solvent alone. There were twenty five replicates of larvae for each individual compound tested. The insects were examined daily for 60 days. The duration of the pupal stage (days) was recorded as well as inhibition of molting imaginal. The results showed that two of the tested compounds affected the normal development of the larvae. These compounds induced different levels of inhibition of molting. Besides the growth inhibitory effects also showed some mortality.