INTEQUI   20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
“Enhancement of Antiproliferative Activity by Molecular Simplification of Catalpol”
Autor/es:
CELINA GARCÍA; LETICIA G. LEÓN; CARLOS R. PUNGITORE; CARLA RÍOS-LUCI; ANTONIO H. DARANAS; JUAN C. MONTERO; ATANASIO PANDIELLA; CARLOS E. TONN; VÍCTOR S. MARTÍN; JOSÉ M. PADRÓN
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Oxford; Año: 2010 vol. 18 p. 2515 - 2523
ISSN:
0968-0896
Resumen:
Two iridoid scaffolds were synthesized enantioselectively using as key step an L-proline-catalyzed a-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38–1.86 lM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G1 phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining.