INTEQUI   20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Preparation and Physical Characterization of a Diclofenac-Ranitidine Co-precipitate for Improving the Dissolution of Diclofenac
Autor/es:
R. GAITANO; N.L. CALVO; G.E. NARDA; T.S. KAUFMAN; R.M.MAGGIO; E.V.BRUSAU
Revista:
JOURNAL OF PHARMACEUTICAL SCIENCES
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2016 vol. 105 p. 1258 - 1268
ISSN:
0022-3549
Resumen:
Mixing aqueous solutions of sodium diclofenac (DIC-Na) and ranitidine hydrochloride (RAN$HCl) afforded an off-white solid (DIC-RAN) that was investigated from the microscopic, thermal, diffractometric, spectroscopic, and functional (chemometrics-assisted dissolution) points of view. The solid has a 2:1 (DIC:RAN) molar ratio according to 1H nuclear magnetic resonance spectroscopy. It is thermally stable, displaying a broad endothermic signal centered at 105C in the thermogram, and its characteristic reflections in the powder X-ray diffractogram remained unchanged after a 3-month aging period. Scanning electron microscopy micrographs uncovered its morphology, whereas the spectral data suggested an interaction between the carboxylic acid of DIC and the alkyldimethylamino moiety of RAN. The dissolution of DIC-RAN was monitored at different pH values by an ultraviolet/chemometrics procedure, beingcomplete within 5 min at pH 6.8. This compares favorably with the dissolution of a DIC-Na sample of the same particle size.