Proceeding Título: Cytotoxic effect of a natural sesquiterpenlactone and derivatives against human tumor cells lines

BEER MF, SÜLSEN V, RETA GF, MARTINO V, DONADEL OJ.

BIOCELL

Instituto de Histología y Embriología ?Dr. Mario H. Burgos?

Lugar: Mendoza; Año: 2015 vol. 39 p. 165 - 165

Cancer is one of the most important causes of death worldwide. Chemotherapy is one of the best options in the treatment of cancer. However, currently used drugs have serious side effects. Sesquiterpenlactones (STLs) have received considerable attention due to their antitumoral activity. In this sense, the aim of the present study was to evaluate the effect of cumanin, a natural STL, and four of its derivatives on three human tumor cell lines. The sylilated derivatives were synthesized using trimethylchlorosilane, dimethylisopropylchlorosilane andterbuthyldiphenylchlorosilane, using imidazol as a catalytic converter.