INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
A chemoenzymatic synthesis of acyclic nucleoside analogues using rabbit muscle aldolase
Autor/es:
PALAZZOLO, M. A.; NIGRO, M. J.; IRIBARREN, A. M.; LEWKOWICZ, E. S.
Revista:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Lugar: Weinheim; Año: 2016 p. 921 - 924
ISSN:
1434-193X
Resumen:
Acyclic nucleosides are potential antiviral and antitumor agents. In this work, their preparation through a novel chemoenzymatic procedure involving the N-alkylation of a nucleobase and the subsequent aldol condensation catalyzed by a dihydroxyacetone phosphate-dependant aldolase (RAMA) is described.
