INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Genotypic, Phenotypic, and Clinical Characteristics of Isolates of Helicobacter pylori from San Luis, Argentina
Autor/es:
MATTANA C.N.; VEGA E.A.; ESCOBAR F.; SABINI L.; ZANON S.; PUIG DE CENTORBI O.N.
Revista:
FOLIA MICROBIOLOGICA
Referencias:
Año: 2007 vol. 55 p. 519 - 524
ISSN:
0015-5632
Resumen:
The vacA and cagA genotypes of Helicobacter pylori exhibited distinct
geographic distribution and correlation with severity of disease. In
the above genotypes (obtained from 150 H. pylori-positive patients--139
with gastritis, 10 with ulcer and 1 patient with gastric cancer)
combinations vacA s1/m1 and s2/m2 were detected using PCR in 75 and 25%
of isolates, respectively, in patients with chronic gastritis. The of
s1/m1 and s2/m2 combinations were also detected from ulcers (60 and
40%, respectively). The cagA was detected in 30% of isolates.
Concentrated culture supernatants of 7 (64%) out of 11 H. pylori
strains induced vacuolization in Vero cells in titers ranging from 1:5
to 1:40. The vacA s1 genotype was significantly associated with, but
not predictive of the presence of vacuolating cytotoxin activity and
the cagA gene.
