CHEMOENZYMATIC SYNTHESIS OF FLUOXETINE PRECURSORS. REDUCTION OF B-SUBSTITUTED PROPIOPHENONES

CAMILA CORONEL; GABRIEL ARCE; CESAR IGLESIAS; CYNTHIA ALEJANDRA MAGALLANES NOGUERA; PAULA RODRIGUEZ BONNECARRERE; SONIA RODRIGUEZ GIORDANO; DAVID GONZALES

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 p. 94 - 98

1381-1177

Five endophytic yeast strains isolated from edible plants were tested in the reduction b-chloro and b-azidopropiophenone for the preparation of optically active fluoxetine precursors. The biotransformation rendered not only the corresponding chiral g-substituted alcohols, but also unsubstituted alcohols and ketones. The product profile was studied and a plausible mechanism for the reductive elimination of the b-functional group is proposed.