INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Chemistry and Biological Activity of Coumarins at Molecular Level
Autor/es:
HUGO A. GARRO; CELINA E. GARCÍA; VÍCTOR S. MARTÍN; CARLOS E. TONN; CARLOS R. PUNGITORE
Revista:
NATURAL PRODUCT COMMUNICATIONS
Editorial:
NATURAL PRODUCTS INC
Referencias:
Lugar: Westerville, Ohio; Año: 2014 vol. 9 p. 1091 - 1094
ISSN:
1934-578X
Resumen:
Synthetic coumarins were prepared in high yields using ionic liquids as an environmental friendly alternative. 3,4-Dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) showed interesting activity against Taq DNA polymerase with IC50 values of 115.7 μM and 82.2 μM, respectively. Also, 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) exhibited inhibitory activity against MMLV-RT with IC50 values of 23.5 μM and 18.3 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also for the development of antitumor drugs.
