INTEQUI   20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
biotransformation of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures
Autor/es:
GUILLERMO SCHMEDA-HIRSCHMANN; CARLOS ARANDA; MARCELA KURINA; JAIME A. RODRIGUEZ; CRISTINA THEODOLUZ
Revista:
MOLECULES
Editorial:
MDPI
Referencias:
Año: 2007 vol. 12 p. 1092 - 1100
ISSN:
1420-3049
Resumen:
Microbial transformation of imbricatolic acid (1) by Aspergillus niger afforded 1α-hydroxyimbricatolic acid (2) while transformation with Rhizopus nigricans yielded 15-hydroxy-8,17-epoxylabdan-19-oic acid (3). When the diterpene (1) was added to a Cunninghamella echinulata culture, the microorganism produced mycophenolic acid (4) and its 3-hydroxyderivative (5). The structures were elucidated by spectroscopic methods. The cytotoxicity of the compounds was assessed towards human lung fibroblasts and AGS cells. While 4 and 5 showed low cytotoxicity with IC50 values > 1000 µM against AGS cells and fibroblasts, 1α-hydroxyimbricatolic acid presented moderate toxicity towards AGS cells and fibroblasts, with IC50 values of 307 and 631 µM, respectively. The structure of 2 is presented for the first time.