Two novel potential anticonvulsivant salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole

JORGE R. A. DÍAZ; JOSÉ C. PEDREGOSA; GERARDO E. CAMÍ; MALVA L. GONZÁLEZ; DANIEL R. VEGA

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY

SPRINGER/PLENUM PUBLISHERS

Lugar: New York; Año: 2011 vol. 41 p. 1114 - 1119

1074-1542

Two crystal structures of sulfonamide salts were studied by X-Ray diffraction. The compound C2H5N4O2S2+.H2O.Cl- (I), (Hats.H2O.Cl, Hats = protonated 5-amino-2-sulfonamide-1,3,4-thiadiazole) crystallizes in orthorhombic space group, P212121, with unit cell parameters a = 10.047(4), b = 5.186(2), c = 16.766(6) Å and the compound C2H5N4O2S2+.CH3O3S- (II), crystallizes in monoclinic space group, Cc, with unit cell parameters a = 5.378(3), b = 19.707(6), c = 10.014(5) Å, beta = 99.97(1)o. The molecules in compound I are arranged in a helix of alternating water and Hats molecules. Helixes are interconnected by hydrogen bonds provided by Cl- ions and one ring with a graph set R64 (12) is determined. The crystal structure of compound II presents mesylate and Hats molecules bonded by two hydrogen bond determining a ring with a graph set R22(8). Both compounds exhibit inhibitory activity to carbonic anhydrase enzyme and potential anticonvulsant properties.2H5N4O2S2+.H2O.Cl- (I), (Hats.H2O.Cl, Hats = protonated 5-amino-2-sulfonamide-1,3,4-thiadiazole) crystallizes in orthorhombic space group, P212121, with unit cell parameters a = 10.047(4), b = 5.186(2), c = 16.766(6) Å and the compound C2H5N4O2S2+.CH3O3S- (II), crystallizes in monoclinic space group, Cc, with unit cell parameters a = 5.378(3), b = 19.707(6), c = 10.014(5) Å, beta = 99.97(1)o. The molecules in compound I are arranged in a helix of alternating water and Hats molecules. Helixes are interconnected by hydrogen bonds provided by Cl- ions and one ring with a graph set R64 (12) is determined. The crystal structure of compound II presents mesylate and Hats molecules bonded by two hydrogen bond determining a ring with a graph set R22(8). Both compounds exhibit inhibitory activity to carbonic anhydrase enzyme and potential anticonvulsant properties.