INTEQUI   20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
A CHIRAL 1,3,2-DIOXABOROLANE DERIVED FROM A NATURAL DITERPENE FOR ASYMMETRIC REDUCTION OF PROCHIRAL KETONES
Autor/es:
DIEGO A. CIFUENTE ; CARLOS E. TONN
Revista:
Organic communications
Editorial:
ACG Pubs.
Referencias:
Año: 2012 vol. 5 p. 77 - 82
ISSN:
1307-6175
Resumen:
The application of a chiral 1,3,2-dioxaborolane, for the sulfide complex-mediated asymmetric reduction of prochiral ketones at room temperature, are described. The B-methoxy-dioxaborolane was synthesized from 2a,3a-dihydroxycativic acid, a labdane-type diterpene isolated from aerial parts of Baccharis scandens DC. Very good chemical yields (85-97%) and high enantioselectivities (62-96% ee), were obtained.