IMIBIO-SL   20937
INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES BIOLOGICAS DE SAN LUIS
Unidad Ejecutora - UE
capítulos de libros
Título:
Lipid metabolism in heart and
Autor/es:
LILIANA B. OLIVEROS, LAURA V. GATICA AND MAR¨ªA S.GIMENEZZ
Libro:
Advances in Lipid Metabolism,
Editorial:
Research Signpost
Referencias:
Lugar: Kerala India; Año: 2008; p. 169 - 192
Resumen:
Abstract
Retinoids, the naturally occurring and synthetic
derivatives of vitamin A, modulate numerous
fundamental physiological processes such as cellular
differentiation, proliferation and apoptosis. The liver is
the main storage site for vitamin A and also regulates the
secretion of retinol into the circulation in response to the
demands of target tissues. The molecular mechanism of
retinoic acid action mainly involves the binding and
activation of specific nuclear receptors, retinoic acid
receptor (RAR) and retinoid X receptor (RXR) that
modulate gene expression. The vitamin A metabolite,
9-cis retinoic acid, is the most potent ligand of RXR.
Correspondence/Reprint request: Dra. Liliana Beatriz Oliveros, Fisiologia Humana, Departamento de
Bioqu¨ªmica y Ciencias Biol¨®gicas, Universidad Nacional de San Luis Avenida Ej¨¦rcito de los Andes 950
CP 5700 - San Luis, Argentina. E-mail: lolive@unsl.edu.ar
It is known that peroxisome proliferator-activated receptors (PPARs) form
heterodimers with RXR to interact with a peroxisome proliferator responsive
element of target gene and to regulate transcriptional expression. Natural fatty
acids are ligands of PPARs, this fact, together with the function of identified
target genes indicate that PPARs play a key role in lipid homeostasis. The
lipoperoxidation induced by vitamin A deficiency has been communicated in
several works. However, the molecular mechanisms underlying the many
effects of retinoic acid on heart and aorta lipid metabolisms are not well
understood. This chapter focuses on the vitamin A influencing cellular and
molecular regulation of lipid metabolism in heart and aorta. In particular, the
functions of PPAR ¦Á on energetic mitochondrial processes in cardiac tissue
and the effects of oxidized LDL in aorta are discussed.
and the effects of oxidized LDL in aorta are discussed.
¦Á on energetic mitochondrial processes in cardiac tissue
and the effects of oxidized LDL in aorta are discussed.