Ribosomes from Trypanosomatids: Unique Structural and Functional Properties

MAXIMILIANO JURI AYUB; WALTER J. LAPADULA; JOHAN HOEBEKE; CRISTIAN R. SMULSKI

Cell-Free Protein Synthesis

In Tech

Lugar: Tokyo; Año: 2012; p. 4 - 28

Trypanosomatids are a monophyletic group of protozoa that diverged early from the eukaryotic lineage, constituting valuable model organisms for studying variability in different highly conserved processes including protein synthesis. Moreover, several species of trypanosomatids are causing agents of endemic diseases in the third world. There are many evidences suggesting that translation in these organisms shows important differences with that of model organisms such as yeast and mammals. These unique features, which have a great potential relevance for both basic and applied research, will be discussed in this chapter.