SPHINGOSINE-1 PHOSPHATE: A NEW MODULATOR OF IMMUNE PLASTICITY IN THE TUMOR MICROENVIRONMENT

CAMPOS L; OSKERITZIAN CA; CASTRO M; RODRIGUEZ Y; ALVAREZ SE; ALADHAMI A

Frontiers in Oncology

Frontiers Editorial Office

Lugar: Lausanne; Año: 2016 vol. 6

2234-943X

In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate22 (S1P) in both normal physiology and progression of different diseases, including cancer and23 inflammation. Indeed, numerous studies show that tissue levels of this sphingolipid metabolite are24 augmented in many cancers, affecting survival, proliferation, angiogenesis and metastatic spread.25 Recent insights into the possible role of S1P as a therapeutic target has attracted enormous attention26 and opened new opportunities in this evolving field. In this review we will focus on the role of S1P in27 cancer with particular emphasis in new developments that highlight the many functions of this28 sphingolipid in the tumor microenvironment. We will discuss how S1P modulates phenotypic29 plasticity of macrophages and mast cells, tumor-induced immune evasion, differentiation and30 survival of immune cells in the tumor milieu, interaction between cancer and stromal cells and31 hypoxic response.