ALTERATION IN THE EXPRESSION OF INFLAMMATORYPARAMETERS AS A RESULT OF OXIDATIVE STRESSPRODUCED BY MODERATE ZINC DEFICIENCY IN RAT LUNG

GOMEZ NIDIA; BIAGGIO, VERÓNICA; PEREZ CHACA, MARIA; VALDEZ, SUSANA; GIMENEZ, MARIA

EXPERIMENTAL LUNG RESEARCH

Informa Healthcare

Lugar: UK; Año: 2009

0190-2148

Abstract Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, we have shown that Zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. The goal of this study is to test the effect of moderate ZD on IGF-1, IGFBP-5, NOX-2, TNFá, as well as the effect of restoring Zinc during the refeeding period. Adult male rats were divided into three groups: Zn- adequate control group, Zn-deficient group and Znrefeeding group. eNOS, MT II and NOX-2 was increased in ZD group. We observed an increased gene transcription of SOD-2 and GPx-1 in ZD group, as well as in ZD refeeding, but CAT transcription did not change in the treated groups. Pro- inflammatory factors, such as TNFá and VCAM-1 increased in ZD, while it decreased in ZD refeeding. However, PPARã and IGF-1 gene transcription decreased in ZD, while IGFBP-5 decreased in the ZD group. These parameters are associated to alterations in the lung histoarchitecture. The zinc supplementation period is brief (only ten days), but it is enough to inhibit some proinflammatory factors. Perhaps, zinc deficiency implications must be taken into account in health interventions because inflammation and prooxidant environment are associated with ZD in lung.