Mecanismos moleculares y terapéuticas para reducir la inflamación del tejido adiposo en la obesidad

GOMEZ-MEJIBA, SANDRA; DARIO C. RAMIREZ

REVISTA PERUANA DE DIVULGACION EN GENETICA Y BIOLOGIA MOLECULAR

Instituto de Genetica Barbara McClintock

Lugar: Lima; Año: 2016 vol. 1 p. 10 - 13

Adipose tissue (AT) inflammation in obesity is a key process linking obesity, systemic inflammation and metabolic syndrome. The understanding of the molecular mechanisms of adipogenesis/adiposity as well as inflammatory activation of macrophages is critical in the search of novel therapeutics to reduce AT inflammation in obesity. Herein, based on our clinical as well as biochemical data we discuss the role of two transcription factors involved in adipogenesis (Nrf-2) and inflammatory activation of macrophages (NF-κB). We focus our discussion on strategies aimed at screening libraries of natural and synthetic compounds in the search for novel structures able to induce Nrf-2 activation in adipocytes and to reduce NF-κB activation in macrophages by using molecular and cellular models. The growing incidence of metabolic syndrome in obesity justifies the search for novelchemical structures to enhance adipogenesis and to reduce AT inflammation.