Reduced blood nrf-2 mRNA in local overweight boys at risk of metabolic complications: a study in San Luis City, San Luis, Argentina.

L. D. SANTILLÁN ¹, M. MOYANO ², M. FRAU ³, O. FLORES ³, S.SIEWERT, F. ZIRULNICK D.C. RAMIREZ4., M. S. GIMÉNEZ ¹

METABOLIC SYNDROME AND RELATED DISORDERS

MARY ANN LIEBERT INC

Lugar: New York; Año: 2013 vol. 11 p. 359 - 365

1540-4196

BACKGROUND: Childhood overweight (OW) is a matter of public health concern because of its long-term impact on adulthood health. NF-E2-related factor 2 (Nrf-2) regulates the antioxidant/lipogenic response to a sustained positive energy balance that prevails during weight gain. Here we aimed at studying a possible link between OW and Nrf-2-dependent antioxidant/lipogenic response in a local population of boys at risk of metabolic complications. METHODS: We measured clinical and biochemical parameters related to lipid metabolism, oxidative stress, and metabolic syndrome in a population of OW boys [body mass index (BMI) percentile ≥85(th) and