IMIBIO-SL 20937
INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES BIOLOGICAS DE SAN LUIS
Unidad Ejecutora - UE
artículos
Título:
New small-size peptides possessing antifungal activity
Autor/es:
F. M. GARIBOTTO, A. D. GARRO, C. SOMLAI, M. F. MASMAN, P. LUTIEN, S. A. ZACCHINO, A. M. RODRIGUEZ, B. PENKE AND R. D. ENRIZ.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2010 vol. 18 p. 158 - 167
ISSN:
0968-0896
Resumen:
The synthesis, in vitro evaluation, and conformational study of a new series of small-size peptides acting
as antifungal agents are reported. In a first step of our study we performed a conformational analysis
using Molecular Mechanics calculations. The electronic study was carried out using Molecular electrostatic
potentials (MEPs) obtained from RHF/6-31G calculations. On the basis of the theoretical predictions
three small-size peptides, RQWKKWWQWRR-NH2, RQIRRWWQWRR-NH2, and RQIRRWWQW-NH2 were
synthesized and tested. These peptides displayed a significant antifungal activity against human pathogenic
strains including Candida albicans and Cryptococcus neoformans. Our experimental and theoretical
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
synthesized and tested. These peptides displayed a significant antifungal activity against human pathogenic
strains including Candida albicans and Cryptococcus neoformans. Our experimental and theoretical
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
synthesized and tested. These peptides displayed a significant antifungal activity against human pathogenic
strains including Candida albicans and Cryptococcus neoformans. Our experimental and theoretical
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
2, RQIRRWWQWRR-NH2, and RQIRRWWQW-NH2 were
synthesized and tested. These peptides displayed a significant antifungal activity against human pathogenic
strains including Candida albicans and Cryptococcus neoformans. Our experimental and theoretical
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
Candida albicans and Cryptococcus neoformans. Our experimental and theoretical
results allow the identification of a topographical template which can serve as a guide for the design
of new compounds with antifungal properties for potential therapeutic applications against these pathogenic
fungi.
