INQUISAL   20936
INSTITUTO DE QUIMICA DE SAN LUIS "DR. ROBERTO ANTONIO OLSINA"
Unidad Ejecutora - UE
artículos
Título:
First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
Autor/es:
MARTÍNEZ, NOELIA A.; BADILLO-GARCÍA, MARÍA LUISA; ARIAS, JOSÉ L.; DELGADO, ÁNGEL V.; CERUTTI, SOLEDAD E.; FERNÁNDEZ-ÁLVAREZ, FÁTIMA; RABA, JULIO
Revista:
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
Editorial:
TAYLOR & FRANCIS INC
Referencias:
Año: 2020 vol. 20 p. 892 - 898
ISSN:
1083-7450
Resumen:
Praziquantel (PZQ), a broad spectrum anthelmintic drug, cannot be found in acceptable dosage forms for elderly patients, paediatric patients, and for veterinary use. In fact, very little has been done up to now in the formulation of liquid dosage forms, being they always formulated for parenteral administration. To beat this important challenge, it was accomplished a comprehensive analysis of the influence of two elementary physicochemical aspects, i.e. surface thermodynamic and electrokinetic properties, on the colloidal stability of PZQ nanosuspensions. The hydrophobic character of the drug, intensely determining the flocculation curves, was confirmed by the thermodynamic characterization. The electrophoretic characterization, in combination with the sedimentation and relative absorbance versus time curves, highlighted that the electrical double layer thickness and the surface charge can play an essential role in the stability of the pharmaceutical colloid. Finally, it was demonstrated that controlling the pH values and the incorporation of electrolytes can help in formulating PZQ aqueous nanosuspensions with appropriate stability and redispersibility behaviours for pharmaceutical use.