INQUISAL   20936
INSTITUTO DE QUIMICA DE SAN LUIS "DR. ROBERTO ANTONIO OLSINA"
Unidad Ejecutora - UE
artículos
Título:
Quantitative structure-activity relationship to elucidate human CYP2A6 inhibition by organosulfur compounds
Autor/es:
EDUARDO MARCHEVSKY; DANIELA ANDREA RAMIREZ; ALEJANDRA CAMARGO; JUAN M LUCO; DANIELA ANDREA RAMIREZ; EDUARDO MARCHEVSKY; ALEJANDRA CAMARGO; JUAN M LUCO
Revista:
ADMET and DMPK
Editorial:
IAPC Publishing
Referencias:
Lugar: HR-10000 Zagreb CROATIA; Año: 2019 vol. 7 p. 196 - 209
ISSN:
1848-7718
Resumen:
CYP2A6 is a human enzyme responsible for the metabolic elimination of nicotine, and it is also involved in the activation of procarcinogenic nitrosamines, especially those present in tobacco smoke. Several investigations have reported that reducing this enzyme activity may contribute to anti-smoking therapy as well as reducing the risk of promutagens in the body. For these reasons, several authors investigate selective inhibitors molecules toward this enzyme. The aim of this study was to evaluate the interactions between a set of organosulfur compounds and the CYP2A6 enzyme by a quantitative structure-activity relationship (QSAR) analysis. The present work provides a better understanding of the mechanisms involved, with the final goal of providing information for the future design of CYP2A6 inhibitors based on dietary compounds. The reported activity data were modeled by means of multiple regression analysis (MLR) and partial least-squares (PLS) techniques. The results indicate that hydrophobic and steric factors govern the union, while electronic factors are strongly involved in the case of monosulfides.