HIGH LEVELS OF LINOLEIC ACID INDUCED BY DIETS RICH IN VEGETAL OILS CORRELATES WITH PARAMETERS DEFINING THE METABOLIC SYNDROME

MEDINA, MIRTA; MEDINA, ANALIA; VANNIEUWENHOVE, CARINA; SAAD DE SCHOOS, SILVIA; JEREZ, SUSANA

Congreso; XXXIII Reunión Anual de la Asociación de Biología de Tucumán; 2016

Asociación de Biología de Tucumán

High-fat diets are associated with obesity and metabolic syndrome (MS). However, the type of fat consumed may be a determining factor to state whether the diet improves or triggers risk factors for cardiovascular disease (CRF). The aim of this study was to evaluate the consumption of vegetal oils rich in fatty acids (FA) n-6 and n-3 related to the parameters defining the MS. Rabbits were fed with normal diet (CD), CD + 1% cholesterol (HD), CD + saturated fat (8% fat pork) and unsaturated (10% corn oil, rich in n-6) (HFD), CD + 10% chia oil, rich in n-3 (CD-Ch), DG + 1% cholesterol (HD-HFD), HD + 10% chia oil (HD-Ch). Hemodynamic and biochemical parameters [blood pressure, heart rate, fasting glucose (GB), glucose tolerance, lipid profile, plasma FA] were determined. Visceral abdominal fat (VAF) was weighed. Animals with diets rich in oils showed: 1) increased GB, VAF and glucose intolerance, 2) high plasma levels of linoleic acid, LA (n-6), and saturated FA and reduced levels of monounsaturated FA, 3) reduced estearoyl CoA desaturase (SCD-18) activity. Regression analysis showed that the LA but not the linolenic acid (n-3) is correlated significantly and positively with GB, glucose intolerance and GVA. LA is very strong and negatively correlated with the activity of the SCD-18. These results show that consumption of vegetable oils rich in n-6 can trigger CRF and that LA plasma levels or SCD-18 activity may be good biomarkers of CRF