IFIMAR   20926
INSTITUTO DE INVESTIGACIONES FISICAS DE MAR DEL PLATA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CAN BACTERIA PREDICT THEIR ENVIRONMENT? PROSPECTS AND IMPLICATIONS
Autor/es:
PABLO ALEJANDRO SÁNCHEZ; PABLO IGNACIO MARTÍN; ENRIQUE REWALD
Lugar:
Granada
Reunión:
Congreso; 8th International Congress on Autoimmunity; 2012
Institución organizadora:
Kenes International
Resumen:
Synchronization of biological clocks is fundamental for the coordination
of rhythmic behavior between elements in a large complex system. It is
known that diverse intercellular coupling mechanisms lead to
synchronized oscillators present in basic physiological functions such
as cardiac function, respiration, insulin secretion, and others.Synchronization
supports stabilize certain behavior arising from a network of
intrinsically noisy and unpredictable elements. Occasionally, however,
synchronization of oscillations can lead to failure in a biological
system, as in epileptic seizures.In this brief presentation we
attempt to extract some essential ingredients and properties that
characterize the phenomenon of anticipated synchronization in the
presence of external additive noise perturbing the dynamical processes
in a population of bacteria. Synthetic biology is a new way to
recreate the complex behavior of cells from biochemical reactions that
govern the genetic regulation and signaling. Nonlinearity and
stochasticity rise naturally from the underlying biochemistry and become
appreciate tools from the fields of nonlinear dynamics and statistical
physics for the generation of experimental and theoretical models. In
these models, the elements of the quorum sensing machineries are
presented as clocks that trigger synchronous behavior in a network
architecture of bacterial individuals. In addition, most quorum sensing
systems involve a critical cell density for generation of coordinated
activity.Finally, we show a possible impact on gastrointestinal autoimmune diseases and prospects for future treatments.