IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Early protein malnutrition attenuates the antidepressant-like effect of DMI in the forced- swim test in adults rats maternally separated
Autor/es:
NASI MEDEOT L; VALDOMERO A; PERONDI MC; GUTIERREZ MC; CUADRA GR
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Conjunta 2016 entre la SAIC, la SAI y la SAFE.; 2016
Resumen:
Previous results demonstrate that perinatal protein malnutrition facilitates depressive-like behaviors in rats thathave experienced maternal separation. Thus, undernutrition significantly increases the immobility time in the forced- swim test (FST). Considering the long-lasting alterations produced in the central monoaminergic systems, as a consequence of nutritional insult, we study the treatment effects of desipramine (DMI) - a highly selective reuptake inhibitor of norepinephrine-on the behavioral changes found in the FST. To this aim, different groups of adult control (C) and protein deprived rats (D) maternally separated daily for 180 min from PND 1until PND 10 (MS-group) were treated with DMI (15 mg/kg/day, IP) or saline during 7 days. Total immobility time wasmeasured for 5 min period in the FST and compared with rats that were not submitted to maternal separation (NMS). Although DMI treatment produced an antidepressant-like effect in both C (NMS and MS) and D (NMS and MS) groups, rats in D-MS group showed a significant higher immobility time in the forced-swim test. These preliminary results indicate that early nutritional insult alter the pharmacological reactivity to DMI, highlighting an incapacity to induce neuroadaptative changes in central pathways involved in DMI mechanism of action. Indeed, they suggest the possibility of an altered reactivity to therapeutic treatments in adult subjects malnourished at early life.