IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
alpha-MSH can modulate LPS+IFN-gamma signaling transduction pathways involved in inflammation.
Autor/es:
· GONZÁLEZ P, CARUSO C, SÁNCHEZ M, CABANILLAS A, LASAGA M, SCIMONELLI T
Lugar:
Tandil
Reunión:
Congreso; XL Reunión Annual de la Asociación Argentina de Farmacología Experimental (SAFE); 2008
Institución organizadora:
Asociación Argentina de Farmacología Experimental (SAFE)
Resumen:
There is evidence that the melanocortin alpha-melanocyte stimulating hormone (a-MSH) has immunomodulatory and anti-inflammatory actions within the brain. The aim of the present study was to establish the effect of a-MSH on LPS+IFN-g-induced signalling pathways in hypothalamic neurones or astrocytes in culture. We found that a-MSH suppresses LPS+IFN-g- induced nuclear translocation of the transcription factor NF-kB. Besides, treatment with LPS+IFN-g stimulates phosphorylation of cAMP-responsive element-binding protein (CREB), but this effect was not modified by a-MSH. In neurones, LPS+IFN-g elicited a slight increase in CREB activation. Treatment with a-MSH induced CREB phosphorylation and the combination of LPS+IFN-g and a-MSH induced an additive increase in CREB activation. Our results demonstrated that a-MSH can differently modulate signalling transduction pathways induced by LPS+IFN-g.