IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Systemic vs. central cyanamide administration modulates the motivational and stimulant effects of ethanol in developmentally low-level lead exposed rats.
Autor/es:
MATTALLONI, M.S; CANCELA, L.M.; VIRGOLINI, M.B.
Lugar:
Valdivia
Reunión:
Congreso; VI Neurotoxicity Society Meeting; 2013
Institución organizadora:
Neutotoxicity Society
Resumen:
SYSTEMIC vs. CENTRAL CYANAMIDE ADMINISTRATION MODULATES THE MOTIVATIONAL AND STIMULANT EFFECTS OF ETHANOL IN DEVELOPMENTALLY LOW-LEVEL LEAD EXPOSED RATS Mattalloni, M.S.; De Giovanni, L.N.; Cancela, L.M.; Virgolini, M.B. IFEC-CONICET. Depto. de Farmacología. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba.Córdoba. Argentina. E-mail: marsol214@hotmail.com   Previous evidences demonstrate a higher reactivity to several effects of ethanol in developmentally low-level lead (Pb) exposed rats. This study aimed to evaluate the influence of cyanamide, a drug that modifies ethanol metabolism by inhibiting ALDH and to a lesser extent catalase, on the motivational and stimulant properties of ethanol. Thirty-five day-old male Wistar pups perinatally exposed to 220 ppm Pb were evaluated in their ethanol intake in a free-choice limited paradigm (2 h) at increasing ethanol concentrations (2-10%); immediately thereafter their ethanol-induced locomotor activity was assessed. Cyanamide was centrally and systemically administered in both tests. The results demonstrated that Pb-exposed rats voluntarily consumed more ethanol and showed ethanol-induced hyperlocomotion in relation to their respective controls, being both effects reversed by systemically-administered cyanamide. On the opposite, when cyanamide was administered centrally, only the control animals evidenced an increase in ethanol intake, although both groups showed an increase in ethanol-induced locomotor activity. The interplay between centrally-formed (reinforcing) and peripheral (aversive) acetaldehyde reveal the importance of ethanol metabolism in the higher motivational and stimulant effects observed in developmentally Pb-exposed rats.