IFEC 20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Exogenous GM1 ganglioside increases the rewarding properties
Autor/es:
VALDOMERO A.; VELAZQUEZ E.E.; ORSINGHER O.A.; CUADRA G.R.
Lugar:
Huerta Grande, Cordoba
Reunión:
Congreso; XXVII Congreso Anual de la Sociedad Argentina de Investigacion en Neurociencias; 2012
Institución organizadora:
Sociedad Argentina de Investigacion en Neurociencias (SAN)
Resumen:
We recently reported that GM1 pretreatment enhances the rewarding properties
of cocaine, evidenced by a reduction of the dose of cocaine necessary to
induce conditioned place preference (CPP), as well as by the number of
sessions necessary for conditioning. To clarify the mechanism of such an effect,
different pharmacokinetic parameters of cocaine, and its inhibitory effect on the
dopamine transporter were evaluated. None of these parameters was modified
by GM1 pretreatment, but it modified the brain cocaine disposition. In order to
explain the effect of GM1 on the rewarding properties of cocaine, in the present
study we examined whether exogenous administration of GM1 induces the
expression of BDNF in the nucleus accumbens (NAc). Thus, adult male rats
were submitted to 3 conditioning sessions with cocaine (10 mg/kg), and
following the CPP test were sacrificed, the NAc was dissected and prepared for
BDNF determination. Only GM1 pretreated rats (30 mg/kg) showed an increase
of the rewarding properties of cocaine, an effect correlated with a significant
increase of BDNF levels in the NAc. These preliminary results, suggest that
GM1 may promote the increase effects of BDNF, by activating mechanisms of
associative learning that underlie the conditioned responses to cocaine.
