IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Modulación del estrés sobre la evocación de una memoria de miedo: consolidación o reconsolidación?
Autor/es:
MOLINA VICTOR ALEJANDRO
Lugar:
Rio de Janeiro
Reunión:
Conferencia; XXVI Reunión Anual de FeSBE; 2011
Institución organizadora:
Federacion de sociedades de bilogia do Brasil
Resumen:
In fear memory protocols, new threatening information undergoes a progressive stabilization process termed consolidation which requires de novo protein synthesis. This process converts the initial fragile trace into an established long-term memory . Upon retrieval and under certain boundary conditions, such memory trace can re-enter a transient labile state which requires a novel stabilization process dependent upon new protein synthesis referred to as reconsolidation. This process is not a faithful recapitulation of consolidation. In fact, non-overlapping and distinctive mechanisms between consolidation and reconsolidation have been described in selected brain regions. We demonstrated the interaction between a stressfulevent and the retrieval phase of a consolidated trace.Such interaction is dependent on BDNF mechanism and not in molecular events that characterize the reconsolidation mechanism. These findings suggest that such interaction is dependent on BDNF consolidation-like mechanism.