IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
libros
Título:
Functional Foods for Chronic Diseases ? 2016 First Edition. Functional Foods for Chronic Diseases Textbook, Volume Two, First Edition. Chapter V. Food Science Publisher 2016. Edited by Danik M. Martirosyan, PhD
Autor/es:
LANCELLOTTI, TANIA E. SAEZ; FUNES, ABI K.; FORNES, MIGUEL W; SIMON LAYLA
Editorial:
Food Science Publisher 2016 Edited by Danik M. Martirosyan, PhD
Referencias:
Lugar: San Diego - California; Año: 2018 p. 5
ISSN:
1536919438
Resumen:
The relationship between obesity/hypercholesterolemia and reduced male fertility has been reported clinically and in experimental models [1]?[12]. The effect of high cholesterol (chol) intake and its impact in different tissue/organs has also been described in several models [13]. The deleterious impact on reproductive tissues has been studied in rabbits and other species [6], [7], [10], [14]?[18]. Changes in lipid content in testis [19] and epididymal cells [20] were reported in normal or genetically reprogrammed animals.Recent work using the hypercholesterolemic rabbit (HCR) (race: New Zeeland) model previously developed to study atherosclerosis [21] demonstrate that: a. increased fat in a nutritionally complete diet alters the cholesterol content and distribution of rabbit sperm membrane. The dietary high fat level has serious consequences on sperm specific functions that depend on membrane integrity/dynamics. At least, two of the proposed pathways involved in regulating sperm capacitation and Acrosomal Reaction (AR) via chol resulted compromised; b. daily virgin olive oil supplementation together with a fat diet provided to male rabbits can restore the hypercholesterolemic (HC) response to basal level with a significant improvement of semen quality.We also concluded that the cellular events implicated must be further investigatedto make harder progress not only in diagnosis and treatment but also in prevention. In this previous works, the sperm morphology was altered in the amount of ejaculated sperm. Taking in account that the final appearance of sperm cell is due to complexes mechanisms that take place in the seminiferous tubules (Kiersenbaum?.). Recent work in our lab was directed to study the Golgi apparatus / acrosome ? acroplaxome development to acquire the sperm head shape.Interesting, olive oil addition to normal diet, avoid semen/sperm and testicular alterations in adult male rabbit [14], [15].