IHEM 20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
artículos
Título:
Autophagy Subversion by Bacteria
Autor/es:
CAMPOY, E.; COLOMBO, M. I.
Revista:
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY
Editorial:
SPRINGER-VERLAG BERLIN
Referencias:
Año: 2009 vol. 335 p. 227 - 250
ISSN:
0070-217X
Resumen:
Autophagy is an important cell survival process during nitrogen starvation conditions and it also has a housekeeping role by removing superfluous or aged organelles. Autophagy has been also linked to host cell control of several intracellular microorganims. However, since it is an important host defense mechanism, some pathogens have also evolved strategies to exploit or subvert autophagy. Thus, certain pathogens harness autophagy leading to persistent infection and pathogenesis. In this chapter we highlight our current understanding of those bacterial pathogens that transit through the autophagic pathway, efficiently replicating and surviving within the host cell. In addition, we discuss present knowledge about how autophagy modulation affects the infectious capacity and the life cycle of several intracellular pathogens.
