IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Poster: Relationship between obesity and adipokines with prostate cancer prevalence and aggressiveness.
Autor/es:
LÓPEZ LAUR J, PEREZ ELIZALDE R, CÓRICA A, UVILLA A, DI MILTA N, MASELLI E, VANRELL C, MESSINA D, LÓPEZ FONTANA C
Lugar:
SAN FRANCISCO (EEUU)
Reunión:
Congreso; AUA annual meeting, San Francisco (EEUU); 2010
Institución organizadora:
AMERICAN UROLOGICAL ASSOCIATION
Resumen:
Introduction
and Objective: Recent
studies indicate that adipose tissue and adipokines might promote or prevent
the development of prostate cancer (PCa). Leptin would have a stimulating
effect on prostate cancer cells by inducing promotion and progression, whereas
adiponectin would have a protective effect. The aim of the present study was to
identify and correlate body composition, leptin and adiponectin levels with the
prevalence and aggressiveness of PCa, in Mendoza, Argentina. Material and
methods: A sample of 50 volunteers between 50 and 80 years (25 healthy men
as control group and 25 with PCa) was selected for the study. Also, the PCa
group was subclassified according to the Gleason score (indicator of
aggressiveness). Rectal examination, transrectal ultrasound and prostatic
biopsy (12-14 cores) were performed; blood sample was obtained to determine
PSA, leptin and adiponectin; and a nutritional interview including
anthropometric measurements and food frequency questionnaire was carried out.
Statistical analysis was performed by Student test, ANOVA and Bonferroni (p
<0.05).Results: The mean age of the volunteers was 62.71 ± 0.97 years
old. Body mass index (BMI) and percentage of body fat mass were not statistically different between the cancer and control groups.
However, both anthropometric variables were higher in subjects with more
aggressive tumors (p <0.05). Cancer patients had lower leptin levels than
healthy subjects. Simultaneously, leptin levels increased with the Gleason
Score (2.96 ± 0.76 ng/ml; 4.57 ± 1.00 ng/ml and 12.09 ± 3.00 ng/ml, p
<0.001). Adiponectin levels showed no statistical differences regarding the
presence and aggressiveness of the tumor (p > 0.05). Finally, consumption
and nutrient intake did not differ according to the groups studied. Conclusions:
Body composition and adipokines are related with the aggressiveness of PCa
rather than its prevalence. Leptin may influence the progression, invasion and
metastasis of prostate tumors, whereas adiponectin may not affect the
carcinogenesis.