IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Hyperthyroidism enhances fetal and placental growth and placental immune cell infiltration
Autor/es:
SÁNCHEZ MARÍA BELÉN; PIETROBON ELISA OLIVIA; JAHN GRACIELA ALMA; NEIRA FLAVIA JUDITH; VALDEZ SUSANA RUTH; MORENO SOSA MARÍA TAMARA; SOAJE MARTA; MACKERN OBERTI JUAN PABLO
Lugar:
Mar del Plata
Reunión:
Otro; Reunión conjunta de Sociedades de Biociencia; 2019
Resumen:
Thyroid dysfunctions cause reproductive disorders as fetal deaths, preterm birth and preeclampsia. Whether thyroid hormones (THs) exert any function in placentalimmune cells is unknown. Therefore, the aim of our work was to assess the influence of hyperthyroidism on placental immune cells as well as the impact on reproduction in pregnant rats. To this end, 10-12 weeks old Wistar rats were injected with a daily dose of T4 (0.1 or 0.25 mg/kg s.c) to induce hyperthyroidism (hyper) or vehicle in control animals. Rats were mated 8 daysafter starting T4 treatment and euthanized on day 19 (G19) and 20 (G20) of gestation. Placenta samples were minced to reach single cell suspension. Then, resident placental immune cells (CD45+) were analyzed by flow cytometry and mRNA content of hormone receptors by qPCR. Also, placental and fetus weightsand fetus number were measured. Hyper mothers delivered more fetuses compared to controls (p