IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
MEDICINAL PLANTS FROM MENDOZA AMELIORATE INTESTINAL PERMEABILITY EX VIVO
Autor/es:
QUESADA, ISABEL; MATILDE DE PAOLA; CLAUDIA CASTRO; CARLOS GONZALEZ QUILEN; CARLOS GAMARRA-LUQUES; MAYRA VILCA; XIMENA TERRA
Lugar:
San Luis
Reunión:
Congreso; XXXVI Reunión Científica Anual de la SBCuyo; 2019
Institución organizadora:
Sociedad de Biología de Cuyo.
Resumen:
Obesity is associated with impaired intestinal epithelial barrier function and an altered microbiome, which contribute to host systemic inflammation. Tessaria abisinthioides (Ta) and Prosopis strombulífera (Ps) are native plants from South-America with reported ethnopharmacological uses. There is no evidence of intestinal health promoting effects of Ta and Ps. Thus, the aim of this study was to analyze the protective effect of Ta and Ps in pig intestinal inflammation induced by Dextran Sulfate Sodium (DSS) ex vivo. Intestinal permeability was evaluated in an ex vivo Ussing chamber system (Dipl.-Ing. Muβler Scientific Instruments, Aachen, Germany) by measuring transepithelial electrical resistance (TEER). Ex vivo Ussing chamber assays showed a 70% reduction in TEER in proximal colons of pigs when they were exposed to 8% DSS during 1 hour (P