IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Quercetin prevents electrophysiological remodeling and reperfusion arrhythmias in dysmetabolic rats
Autor/es:
PRADO NJ; DIEZ ED, LUCERO GA, PONCE ZUMINO AZ,MIATELLO RM.; DIEZ ER; MIATELLO RM; VAZQUEZ-PRIETO MA
Lugar:
Paris
Reunión:
Congreso; ESC Congress 2019 together with World Congress of Cardiology; 2019
Institución organizadora:
European Society of Cardiology
Resumen:
BACKGROUND: Severe arrhythmias during reperfusion of myocardial infarctionsare associated with increased mortality. High fat and fructose diet (HFFD) increases arrhythmic risk and predispose to diseases such as diabetes, hypertension, and dyslipidemia. Quercetin is a bioactive flavonol found in grapes and grapes derived products. This flavonoid has been proposed to prevent cardiovascular disease, but little is known about its electrophysiological properties.OBJECTIVE: To evaluate electrophysiological effects of chronic quercetin administration in rats with increased arrhythmogenesis during the reperfusion due to a HFFD. METHODS: Male Wistar rats were fed for six weeks with control diet (C), HFFD (20 % fat and 20% fructose w/w), HFFD supplemented with quercetin in a dose of 20 mg/Kg/day (HFFDQ) or quercetin alone (Q). Isolated hearts were perfused with a Krebs-Henseleit solution and after 15 min stabilization, submitted to 10 min of regional ischemia followed by10 min of reperfusion. Epicardial action potential and arrhythmic events were analyzed.RESULTS: HFFD and HFFDQ developed metabolic syndrome, but action potential at 90% of repolarization lengthening only increased in HFFD (78±8 vs 55±8 ms, P