IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ENDOTHELIALS PROGENITORS CELLS IN VASCULAR REMODELING ASSOCIATE TO METABOLIC SYNDROME
Autor/es:
RENNA NF; LEMBO, C; GONZALEZ SE; CASTRO C; MIATELLO RM
Lugar:
Belo Horizaonte, Brazil
Reunión:
Congreso; XVII Congresso Brasileiro de Hipertensão / IASH 2009; 2009
Institución organizadora:
Inter-american society of Hypertension and Sociedad Brasileira de Hipertensão
Resumen:
Although the experimental evidence available demonstrates that the EPCs would contribute in a tissue revascularization, the importance of its use at clinical level remains stranger. It has been postulated which the endothelials cells that participate in the process of lesion-repair can be originated from preexisting blood vessels adjacent or from the circulating recruitment of EPCs derived from bony marrow. The objective was to examine the participation of endothelial progenitors cells (EPC) CD34+/KDR+ in the vascular remodeling physiopathology in mesenteric vascular tissue in a metabolic syndrome (SM) model. The data contribute to uphold the hypothesis that vascular repair by EPCs is altered or diminished in the process of vascular remodeling in mesenteric arteries associated with this experimental model of metabolic syndrome. In vascular wall increase in CD34+ cells in the wall of smooth muscle cells may contribute to vascular hyperplasia. This finding can partly contribute to elaborate new tools, nonpharmacological or pharmacological, to diminish the final organ damage undergone by this experimental model, thus lowering the cardiovascular risk of developing atherosclerotic disease and therefore myocardial infarction or stroke.