IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
NEUROPROTECTIVE EFFECTS OF 17B-ESTRADIOL ADMINISTRATION ON DOPAMINERGIC SYNTHESIS IN AN ANIMAL MODEL OF PARKINSON DISEASE
Autor/es:
VALDEZ, SR; BONACCORSO MARINELLI, MP; CABRERA, RJ; GOMEZ SE
Lugar:
BUENOS AIRES
Reunión:
Congreso; SAIC; 2019
Institución organizadora:
SOCIEDAD ARGENTINA DE INVESTIGACIONES CLINICAS
Resumen:
Substantia nigra (SN) is the most affected structure by the dopaminergic loss in Parkinson's Disease(PD). AfterAlzheimer?s disease, PD is the second most common neurodegenerative disease where age is its strongest riskfactor. What is more, sex also influences disease risk PD incidence , which is 1.5 times higher in men than in women.The reasons underlying these differences are poorly understood and most likely involve a combination of geneticeffects, lifestyle exposures, hormonal/reproductive factors and differences in structure or function of the braindopaminergic pathways.In this work we investigate 17ß-estradiol (E) neuroprotective actions in adult male rats brain after neurotoxic injurywith 6-OHDA. Using inmunohistochemical techniques (IHQ), we label and localize neurons that experess tyrosinehydroxylase (TH+) on substantia nigra (SN) and their projections to corpus striatum (CS). TH is the first enzyme indopamine (DA) biosynthesis and catalyses the conversion of L-tyrosine toL-DOPA. We use it to quantify cell loss in SN and analyze striatal dopamine depletions in nigrostriatal pathway.