IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Pharmacological actions of allopregnanolone ovar the ovarian phisiopathology, different experimental models
Autor/es:
PELEGRINA, LAURA T; DIAZ TORGA, G; CACERES, A. R.R.; CAMPO VERDE ARBOCCO, FIORELLA; ABRHAMOVICH, D; SANHUEZA, M.A; RODRIGUEZ, GRACIELA; LACONI, MYRIAM R
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Anual SAIC ? SAFE ? SAB ? SAP 2019; 2019
Institución organizadora:
Sociedad Argentina de Investigacion clinica
Resumen:
Allopregnanolone (ALLO) is a neurosteroid derived from progesterone, its actions in the CNS are well know. ALLO modulate GABA neurotransmission and induce antidepressant, anxiolytic, anticonvulsant and anesthetic effects. ALLO levels fluctuate under stress and throughout the menstrual cycle, pregnancy and menopause. The objective of this work was to evaluate ALLO action over the female rat ovarian physiopathology since the global effect on the CNS to the action on the granullosae cells. We designed different experimental models in order to differentiate four levels of action. After a dose/response curve we found that ALLO 6µM, a pharmacological dose, was capable of disrupting the hypothalamus-hypophysis-ovarian axis causing a significant ovarian morpho-physiological changes (augmented follicular atresia p