IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ANANDAMIDE DECREASES BLOOD PRESSURE, NEUROINFLAMMATORY AND OXIDATIVE MARKERS IN A RAT MODEL OF HYPERTENSIVE DISEASE
Autor/es:
FERES MOCAYAR; GARCÍA SEBASTIÁN; WALTER MANUCHA; LUCIANA MAZZEI; ROBERTO YUNES; VIRNA MARTÍN GIMENÉZ; DIEGO KASSUHA
Lugar:
Mendoza
Reunión:
Jornada; XXXVI Reunión científica anual de la sociedad de biología de cuyo; 2018
Institución organizadora:
Sociedad de Biología de Cuyo
Resumen:
Essential hypertension is considered one of the significant risks of cardiovascular diseases; it is frequently related with an upregulation of the renin-angiotensin-aldosterone system (RAAS), an over-excitation of brainstem centers, sympathetic hyper activation, imbalance in the levels of oxidative stress biomarkers, pro- and anti-inflammatory cytokines. Spontaneously hypertensive rats (SHR) is a validated model of hypertension, plus several neurocognitive deficits, e.g., attention-deficit/hyperactivity disorder (ADHD). Since endocannabinoid anandamide (AEA) protects neurons from the inflammatory damage, and cannabinoid signaling decreases in brains of hypertensive animals, we applied a nano-formulated AEA in SHR. We used adult male rats (n=7) of 250-300 g normotensive (WKY) and hypertensive (SHR), treated or not with nano-formulated AEA in polycaprolactone (AEA/PCL), at a weekly dose of 5 mg/Kg IP, for four weeks. Regarding WKY, the SHR showed elevated inflammatory markers (IL-1, IL-6, FNTα, ultrasensitive CRP and plasma Hsp-70, p