CONICET | Buscador de Institutos y Recursos Humanos

For general population, inflammation plays a central role in the pathological processes of atherosclerosis, more prominent in patients with Diabetes1 and in particular in individuals with type 1 Diabetes Mellitus (DM1). Studies show elevations of C-reactive protein (CRP) in the first year of diagnosis of DM12 and Interleukin-6 (IL6) and fibrinogen are elevated in patients with DM1. Inflammation, is evident early after diagnosis even in young people with DM1.The role of oxidative stress and inflammation in the progression of vascular complications of DM is well established. The mechanisms are greater in people with DM1: hyperglycemia, hypoglycemia, altered fat distribution, increased adipokines, etc. Diabetes and overweight / obesity are associated with persistent systemic inflammation. Contrary to previously, the prevalence of overweight / obesity in people with DM1 is now similar to the general population (≈60%). Obesity increases the risk of comorbidities in people with DM1, especially metabolic syndrome, and micro and macrovascular disease. Cardiovascular disease is 3 to 7 times more frequent in people with DM1 and, unlike DM2, in DM1 inflammation is a greater risk factor than LDL-cholesterol, and an equal risk factor to that of smoking, in the development of CVD. Regular exercise reduces cardiovascular risk by interfering with pathological mechanisms of atherosclerosis at different levels. Exercise produces a short-term inflammatory response with increased oxidative stress and increased levels of CRP, followed by a long-term anti-inflammatory effect. Poor adherence to exercise routine and exercise costs are a problem. The aim: to evaluate the impact of a simple exercise program and lifestyle on markers of inflammation and oxidation, in people with DM1, and with overweight or obesity.