IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
EFFECT OF MILD HYPERTHYROIDISM ON GLUCOCORTICOID SECRETION INDUCED BY ACUTE STRESS IN PREGNANCY AND LACTATING RATS.
Autor/es:
PIETROBON E; NEIRA F; SOAJE MARTA; MORENO SOSA TAMARA; VALDEZ SUSANA; SANCHEZ B; GRACIELA A. JAHN
Lugar:
Mar del Plata
Reunión:
Congreso; reunion cientifica anual SAIC, SAFE, SAFIS; 2018
Institución organizadora:
SAIC, SAFE, SAFIS
Resumen:
Disorders in thyroid function are associated with anxiety and depression. Therefore, responses to stress may be altered in patients with thyroid diseases. Stress is associated with functional changes in brain areas such as the hippocampus (HpC) and medial basal hypothalamus (MBH) by activating the hypothalamic-hypophysis-adrenal axis (H-H-A) and the consequent release of glucocorticoids in response to the stressor. In this study we analyzed the effects of mild hyperthyroidism on corticosterone response (measured by RIA) to acute stress (exposure to ether vapors for 2 min.) and on the expression (by qPCR) of the glucocorticoid receptor (GR) and the long isoform of the prolactin receptor (PRLRL) in MBH and HpC in Wistar female rats in different reproductive states (day 19 of gestation (G19), 2 (L2) and 12 (L12) of lactation). Hyperthyroidism (hyperT) was induced with T4 (0.1mg /kg/day, s.c.) a dose of that allows the maintenance of lactation. Control (Co) and hyperT rats were bled from the tail vein during the 2 min ether exposure (s1) and 5 min after ether exposure (s2). In G19 acute stress induced corticosterone release in Co group (P