IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
EXACERBATION OF EXPERIMENTAL PSORIASIS SYMPTOMS IN DESMOGLEIN-4 DEFICIENT RATS IS MEDIATED BY INCREASED INFLAMMATION
Autor/es:
SANCHEZ B; GRACIELA A. JAHN; MORENO SOSA TAMARA; ELISA O. PIETROBON; NEIRA FLAVIA; MACKERN JUAN PABLO
Lugar:
Mar del Plata
Reunión:
Congreso; reunion cientifica anual SAIC, SAFE, SAFIS; 2018
Institución organizadora:
SAIC, SAFE, SAFIS
Resumen:
Psoriasis is a chronic inflammatory skin disease,characterized by keratinocyte hyperproliferation,vasculature growth and leukocyte infiltration into thedermis and epidermis. Keratinocytes (KC) produce severalinflammatory factors that modulate leukocytes. It is knownthat desmogleins are proteins present in keratinocytesinvolved in cell adhesion mechanisms and are crucial inkeeping structural integrity of different tissues, includingskin. They also play important roles in differentiation, cellactivation and migration, but their role in psoriasis has notbeen addressed. The aim of our work was to assess theimpact of desmoglein-4 deficiency in the immunological response of the skin