Cardiovascular Diseases and Diabetes: Effect of oxidative stress, inflammation and angiogenesis on the vascular wall.

ISABEL MARÍA QUESADA

MENDOZA

Simposio; I SIMPOSIO DE MEDICINA TRASLACIONAL; 2018

The Vascular Biology laboratory develops activities related to the study of Oxidative Stress associated with cardiovascular diseases and Diabetes. We study the relationships between biological oxidations, hypercholesterolemia, insulin resistance and atherosclerosis. We studied the participation of the arterial wall, from the endothelium, the intima-media layer, the adventitia, to the perivascular adipose tissue, in the establishment and development of atherosclerosis, with emphasis on the inflammatory and angiogenic proteins involved in the process. Regarding oxidative stress, our aim is to study the regulation and expression of the NADPH oxidase system found in the arterial wall consider as the main system capable of generating oxidative stress in the vessel.For our studies, we use cell cultures and animal models of hypercholesterolemia (Apolipoprotein E-deficient mice (ApoE - / -), or Diabetes (chronic fructose administration). Different natural compounds (autochthonous plants), Nox small molecule inhibitors and drugs (sensitizers to Insulin and formulations with nanoparticles) are tested in order to find possible therapeutic compounds that decrease the production of Reactive Oxygen Species, improve endothelial function, reduce inflammation or avoid atheroma plaque vulnerability.