IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
LH and FSH promote breast cancer cell migration and invasion through regulatory actions on the actin cytoskeleton
Autor/es:
FLAMINI MARINA INES; CONTE GRAND J; SANCHEZ ANGEL MATIAS; MONDACA JOSELINA MAGALI
Lugar:
Roma
Reunión:
Congreso; 2nd Global Insight Conference on Breast Cancer; 2017
Institución organizadora:
Innovinc
Resumen:
Title: LH AND FSH PROMOTE BREAST CANCER CELL MIGRATION AND INVASION THROUGH REGULATORY ACTIONS ON THE ACTIN CYTOSKELETONName: Angel Matias Sanchez, PhDSignal Transduction and Cell Movement Laboratory. Institute of Medicine and Experimental Biology of Cuyo (IMBECU), National Research Council of Argentina (CONICET), Parque General San Martin s/n, CP:5500 Mendoza, Argentina.Reproductive hormones influence breast cancer development and progression. While the actions of sex steroids in this setting are established, tentative evidence suggests that follicle-stimulating hormone (FSH) and luteinizing hormone (LH) may also play a role, yet this remains elusive. We here identify that T-47D breast cancer cells express functional receptors for FSH and LH, and that these hormones regulate breast cancer cell motility and invasion through the control of the actin cytoskeleton and the formation of cortical actin aggregates and focal adhesion complexes. Such actions are mediated by the cytoskeletal controllers Moesin and focal adhesion kinase (FAK). Moesin is recruited rapidly by FSH and LH through a signaling cascade requiring the G protein Gα13 and the Rho-associated kinase, ROCK-2. FSH and LH activate FAK via a Gαi/β and c-Src-dependent signaling cascade. Both cascades involve signaling to phosphatidylinositol-3 kinase and Akt. FSH and LH receptors and the related signaling intermediates are necessary for the actions of gonadotrophins on breast cancer cell cytoskeletal rearrangement, migration and invasion. These findings provide original information on the actions of gonadotrophins on breast cancer cells and may have clinical implications for the use of drugs that modulate gonadotrophins in breast cancer patients.Biography Born in Argentina in 1977, he obtained his degree in Molecular Biology from National University of San Luis in 2004. In 2006 he was incorporated at MCGEL laboratory (Italy) where he began to study neuronal and breast cancer cell movement, and in 2010 he received the Ph.D. from Pisa University. In 2011 he was incorporated at IMBECU-CONICET Mendoza. In 2016 he was assigned Chief of Signal Transduction and Cell Movement Laboratory, Institute of Medicine and Experimental Biology of Cuyo, National Research Council of Argentina, Mendoza, Argentina.Presenting author details Full name: PhD Angel Matias Sanchez Contact number: +54-261-5244192 Twitter account:- Linked In account:-Session name/ number: Metastatic Breast Cancer