Software Application To Monitor Neurodegenerative Motor Diseases

RJ CABRERA; MP BONACCORSO MARINELLI

Otro; World Gene Convention; 2017

1. Software application nowadays is a valuable tool to monitor movement disorders associated to neurodegenerative diseases. Automated development has been implemented to evaluate motor signs including voluntary and involuntary actions like muscle problems, rigidity, dystonia, chorea, tremors, bradykinesia, gait disorders and impaired posture and balance. In particular this approach has increased the amount of parameters assessed and it includes an statistic module to make inferences and a graphic interface to present results. In addition, there is no need for special equipment for it to function.2. 17β-Estradiol chronic administration on an animal model of Parkinson Disease (PD) was implemented to evaluate forelimb motor parameters by means of software. Program application increased the number of parameters and accurately evaluated them. What is more, it contributed on describing nigrostriatal dopamine dysfunction and revealing 17β-Estradiol's neuroprotective effects in vivo in PD. Special attention should be placed on 17β-Estradiol as a neuroprotective drug. When administrated on hemiparkinsonian animals, they exhibited less neurodegenerative signs in every test performance. Showing compensatory mechanism on motor dysfunction by increasing balance, mobility, speed and decreasing bradykinesia and stiffness. Particularly in reference to forelimb motor parameters, we noticed an improvement on the number of adjusting steps and less latency in initial time. Also, there is a higher average energy that could be enhancing stepping time and forelimb movement magnitude. In conclusion, this software development and implementation is a worthy tool to in vivo infer on movement disorders, specially forelimb akinesia. By applying it, we obtained a new sensitive approach in the effect of 17β-Estradiol as a neuroprotective drug in PD.