El consumo moderado de vino tinto mejora el balance de las adipocitoquinas en ratas con síndrome metabólico

VAZQUEZ-PRIETO MA, CACCIAMANI V, GONZALEZ ES, LAMA MC, MIATELLO RM.

Hotel Sheraton, Buenos Aires

Congreso; XXVII Congreso Nacional de Cardiología; 2009

Federación Argentina de Cardiología

Dysregulation of adipocytokines secretion is related with the development of metabolic syndrome (FFR). The aim was evaluate the effect of moderated consumption of red wine on adipocytokines expression, vascular inflammation and oxidative stress in FFR rats. Forty male Wistar rats were divided in four groups (n=10 e/g): control (C), FFR (10% fructose in drinking water for 10 w), FFR + 10% ethanol and FFR + red wine malbec (35%) during the last 4 w. Metabolic variables; plasma insulin (Ins); HOMA IR; systolic blood pressure (PAS); aorta NAD(P)H oxidase activity; plasma TBARS, and vascular remodeling in mesenteric were determined; Nox4 and VCAM-1 in mesenteric tissue, and resistin and adiponectin expression in adipose tissue by western blot. FFR significantly increase the Ins, TG, HOMA IR (p<0,05), PAS (p<0,01), NAD(P)H oxidase and Nox4 expression (p< 0,05), TBARS (p< 0,01), resistin and VCAM-1 expression(p<0,01) and decrease adiponectin expression (p<0,01) vs C. Red wine reverts the variables nentioned and increase HDL cholesterol compared with FFR. FFR+Ethanol  only reduced PAS (p<0,01). Red wine independently of ethanol content improve the adipocytokines balance, oxidative stress and vascular inflammation in a model of metabolic syndrome.