IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Nanotoxicology : Acute toxicity assessment of engineered nanostructured aluminium oxide.
Autor/es:
STADLER, T., G. E. LASCALEA AND G. A. JAHN
Lugar:
UADE, Lima 717, Ciudad Autónoma de Buenos Aires
Reunión:
Jornada; XXVI Jornadas Interdisciplinarias de Toxicología - Jornadas Internacionales de Toxicología e Inocuidad Alimentarial; 2008
Institución organizadora:
Asociación Toxicológica Argentina
Resumen:
Nanotoxicology : Acute toxicity assessment of engineered nanostructured aluminium oxide.   Nanotoxicología : Evaluación de la toxicidad aguda de oxido de aluminio nanoestructurado.   Stadler*, T., G. E. Lascalea* and G. A. Jahn**   * Laboratorio de Investigaciones y Servicios Ambientales Mendoza (LISAMEN), CCT-CONICET-Mendoza. Av. Ruíz Leal s/n Parque General San Martín. (5500) Mendoza – Argentina; lpe@lab.cricyt.edu.ar ** Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-CONICET-Mendoza. The rapid proliferation of engineered nanomaterials and the limited toxicological data currently available on it, presents a dilemma to regulators regarding risk assessment processes for these materials. The acute oral toxicity (OECD 408) and the acute inhalatory toxicity (OECD 403) of engineered aluminium oxide nanostructured particles (NAOP) (avge. 100 nm) were assessed in Wistar albino rats. Acute oral toxicity was assessed by a Limit Test at a test dose of 2000mg/kg b. wt., that was administered in a single dose. No mortality was observed in treated animals; no significative differences in body weight were assessed (p<0.05) and no morphological changes were observed through pathological examinations. For the inhalatory administration, the rats were placed in a whole body exposure system. Two concentrations were administered: 0.07mg/L and 0.02mg/L air respectively during 4 hours exposure.  In the 0.02mg/L no changes in body weight gain were noted. A decrease in body weight gain was observed in the 0.07mg/L exposure groups reaching a statistical significant degree (p<0.05). The information on acute toxicity of NAOP generated by this study is applicable to this early stage in the hazard identification process for some nanomaterials that could be useful in risk management in the context of production, handling, and use of nanomaterials.