IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
PROGESTERONE HAS A NEUROPROTECTIVE EFFECT AND PREVENTS DEPRESSION SIGNS IN A MALE RAT DEPRESSION LIKE MODEL
Autor/es:
MARÍA BELÉN MULLE BERNEDO; ROBERTO YUNES; VANINA ANABEL VILLEGAS; ANTONELLA ROSARIO RAMONA CÁCERES GIMENEZ; SEBASTIÁN GARCÍA; RICARDO CABRERA
Lugar:
Mar del plata, Buenos Aires
Reunión:
Congreso; Reunión Conjunta 2016 entre la Sociedad Argentina de Investigación Clínica (SAIC), la Sociedad Argentina de Inmunología (SAI) y la Sociedad Argentina de Farmacología Experimental (SAFE); 2016
Institución organizadora:
Sociedad Argentina de Farmacología Experimental (SAFE)
Resumen:
Depressionis one of the psychiatric disorders with the highest incidence in the recentdecades. It has been recently related to different neurodegenerative diseases suchas Parkinson. These pathologies often appear associated to a premotor sign suchas depression and decreased cognitive performance. The objective was to studyand evaluate if the treatment with the neuroactive steroid progesterone could preventthe development of premotor early signs of neurodegenerative diseases in amodel of catecholaminergic depletion by reserpine. Sprague-Dawley male rats  (250-350 g), between 60 and 90 days old were used. Theexperimental groups were: C (saline), R (reserpine 0.1 mg/kg/sc, 10 injectionover the course of 20 days), P (progesterone 4 mg/kg/sc) alone, 5 days after deexperiments and PP + R (reserpine 5 days after a previous dose ofprogesterone). During the course of reserpine treatment the animals wereevaluated in the catalepsy test. Forced swimming and novel object recognitionwere tested before the appearance of the motor signs. Data were analysed byANOVA-1 and Tukey`s post hoc. A significant decrease (P<0.05) was observedbetween the R vs C groups in all evaluated behavioural parameters. There wereno significant differences in the catalepsy time in the PP+R vs C. AlthoughPP+R vs R, showed a significant increase in the time spend swimming on the forceswimming test (p<0.05) and in the discrimination index (p <0.05) in novelobject recognition.We conclude that a previous progesterone treatment can avoiddepression like behaviour and improves short time memory and the on/ off effecton locomotor activity. Progesterone exerts a neuroprotective effect against thereserpine treatment, preventing cognitive and depression premotor disordersinduced by catecholamine depletion.