Se is able to counteract the inhibitory effects of Te on self-defense and social behavioural activity in the rat.

AGÜERO CARLA; RATTI S.G.,; ALVAREZ EO; OROZCO AA

Mar del P¨lata

Congreso; LXI Reunión Anual de la SAIC, Mar del Plata 16 - 19 Noviembre 2016.; 2016

Sociedad Argentina de Investigación Clínica

Previously in our laboratory, evidence was presented showing that after systemic administration of Te in non-toxic doses to pregnant mother and its litter rats, several behavioural parameters related to motivated and lateralized exploration in the offspring were affected. Administration of systemic Se simultaneously with Te, blocked the inhibitory effect of Te on lateralized exploration, recovering the spontaneous left-biased exploration of animals in a double lateral hole-board labyrinth. In the present complementary work, the possible effect of Se on the inhibitory action that Te has on social and defensive behavioural activity, two important processes to the animal was studied. Four experimental groups were formed. Animals that received water (Control, n=10); animals that received ZnTe (0.03μg/L; n=10); animals that received Na2O3Se (0.268μg/L; n=10), and animals that received Na2O3Se + ZnTe (n=10). Treatments started with the pregnant mother and were continued along delivery, lactation and prepuberal stage of litter rats. At 30 day of age of the offspring, animals were tested individually in an intruder-resident (SIT), and a forced swimming test (FST) to measure social interaction and defense behaviour. Results in the SIT shown that, animals receiving ZnTe, latency to confront the intruder was significantly increased compared to control (131±36.5 Counts/3min Vs 13±3 Counts/3min, p